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Old 05-22-2011, 08:59 PM   #1
rwymk7607
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Default 昼夜规律与用药有什么关系

我们人体有生物钟,它的活动是有一定规律的,即周期节律性。正常人的体温、心率、呼吸、血压、激素分泌等所 呈现的昼夜周期节律性变化,都与此有关。如能熟练掌握此规律,正确的因时给药,则可收到事半功倍之效。现介 绍几种病的最佳给药时间。高血压:正常人血压有生理性曲线变化,即夜间下降,白昼上升。现已知 血压在早晨8-9时和下午5-6时最高,故应在早晨8时和下午5时用降压药效果最好。冠心病:6-11时冠状动脉血流明显减少,是心肌供血不足的高峰,此时也最容易发生心绞痛。故上午用药比下午用药更有效 。急性心功能不全:主要指急性左心功能不全,其表现为呼吸困难,多发生于夜间熟睡时,因此治疗用药最佳时间 为凌晨3-4时。支气管哮喘:人在熟睡时,机体皮质激素水平最低,哮喘也多发生在此时,故夜间用糖皮质激素疗效显著。 而白天用氨茶碱比夜间用更好。消化性溃疡病:经动态测定胃酸分泌在5-11时最少,下午2时到第二天凌晨最高。故用甲氰咪服类治疗时,应在每日下午或临睡前一次服药。糖尿病:糖 尿病人由于胰岛素分泌能力低下,通常在5-9时血糖水平升高。故患者应在早晨5-6时注射胰岛素或用其他降血糖药,则疗效最佳。以上是一些特殊用药情况,在平时最多用的是一日二次、三次、 四次。如一日三次,许多患者误认为仅指白天而言,按上午、中午、下午各服一次。其实指的是24 小时,水宜生官方网站,应每隔8小时服一次药,这才符合昼夜药物在人体血液的浓度规律变化。
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