There have been rare reports of transient healing of gastric ulcers despite subsequently documented malignancy.
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The intersubject variability (%CV) for sirolimus trough concentrations ranged from 39.7% to 68.7%. There was no significant effect of multiple-dose sirolimus on cyclosporine trough concentrations following Sandimmune® Oral Solution (cyclosporine oral solution) administration.
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Variability in metabolism — A subset (about 7%) of the population has reduced activity of the drug metabolizing enzyme CYP2D6. Such individuals are referred to as “poor metabolizers” of drugs such as debrisoquin, dextromethorphan, and the tricyclic antidepressants (TCAs).
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For infections of the ear canal (otitis externa):neomycin (Ak-Spore HC, Cortisporin, Neotricin HC, Ocutricin-HC), polymyxin B, and hydrocortisone (Cortisporin, Otocort, Poly Otic), two drops in the ear canal four times per day for five days, may also be used.
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Within 1-2 days, the rash develops into the typical target lesion.
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The effusion can raise the pressure inside the pericardium causing cardiac tamponade that prevents the heart muscle from contracting and beating adequately.
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Your ophthalmologist may schedule your follow-up visits in accordance with the particular drug you are taking, because some medicines (eg, latanoprost [Xalatan], travoprost [Travatan], bimatoprost [Lumigan]) may take 6-8 weeks to be fully effective.